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Levels of PCDDs,PCDFs in Shenzhen maternal breast milk:Estimation of breast-feeding infant intake

【摘要】:正To evaluate the body burden of polychlorinated dibenzo-p-dioxins(PCDDs),polychlorinated dibenzofurans(PCDFs) and assess their health risk to breast-feeding infants of Shenzhen. Congener-specific analyses of PCDD/Fs were performed on 60 breast milk samples in Shenzhen.China. The range of upper-bound total-TEQ of PCDD/Fs in samples was 2.45-29.01 pg TEQ g~(-1)lipid(mean:8.65 pg TEQ g~(-1) lipid,median:7.75 pg TEQ g~(-1) lipid)(based on 1998-WHO-TEF).and 1.72-24.6 pg TEQ g~(-1)lipid(mean:7.16 pg TEQ g~(-1) lipid,median:6.34 pg TEQ g~(-1) lipid)(based on 2005-WHO-TEF). Significant positive correlations were found between inhabitation period(r=0.49,p0.05),the amount of consumption of fish(r=0.37,p0.05) and the body burden of PCDD/Fs.But the correlation was found between participant's age and the body burden of PCDD/Fs when 1998 WHO-TEF was used for calculation the TEQ(r=0.26,p0.05),but no correlation between them was found when 2005 WHO-TEF was used. The mean estimated daily intake of PCDD/Fs(EDI) by breast-feeding infants was 33.71 pg TEQ g~(-1) bw per day(based on 1998-WHO-TEF) and 27.97pg TEQ g~(-1) bw per day(based on 2005-WHO-TEF).In the study, both the TEQ body burden of the sample population and the EDI of breast-feeding infants were higher than those of 12 representative Chinese areas.Continuous surveillance on PCDD/Fs levels in human milk is needed to correctly evaluate both the environmental impact and human health exposure risk in Shenzhen.

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