收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

The detrimental effects of long-term elevated serum uric acid on cognitive function in rats

Tian Tian  Xi-run Liu  Ting-ting Li  Zhi-chao Nie  Shuang-jing Li  Yan Tang  Cong-wei Gu  Wang-dong Xu  Hong Jia  
【摘要】:Background:Uric acid,a powerful antioxidant,may have neuroprotective properties.But elevated serum uric acid is association with cardiovascular diseases that predispose individuals to cognitive impairment.Findings from studies on uric acid and cognitive function were inconsistent.The effects of uric acid on cognitive function may be related to the concentration and exposure period of uric acid.Therefore,we aimed to explore the effects of long-term elevated serum uric acid on the cognitive function and hippocampus.Methods:The hyperuricemia rats were successfully established at 6~(th) week and maintained until 48~(th) week.Serum uric acid level was measured in blood sample of rat.The spatial learning and memory abilities of rat were assessed by Moris Water Maze test.The pathological changes of hippocampal CA1 and CA3 regions of rat were observed.Oxidative stress,inflammatory cytokines and β-amyloid peptide of rat hippocampus were also measured.Results:Long-term elevated serum uric acid impaired the spatial learning ability of rat and was significantly associated with pathological injuries of hippocampal CA1 and CA3 regions.Meanwhile,long-term elevated serum uric acid induced oxidativu stress,and overexpression of tumor necrosis factor-α and β-amyloid peptide in rat hippocampus.Oxidative stress was significantly correlated with tumor necrosis factor-α and β-amyloid peptide levels in rat hippocampus.In addition,we also found that the detrimental effects of elevated serum uric acid on cognitive function exerted only when the serum uric acid concentration reached a certain level.Conclusion:Findings of our study indicated that long-term elevated serum uric acid was significantly associated with cognitive impairment risk.Oxidative stress,tumor necrosis factor-α and β-amyloid peptide may mediate the pathogenesis of cognitive impairment induced by uric acid.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 ;Research on elevated temperature deformation behavior of Ti-6Al-4V sheets[J];Rare Metals;2009年06期
2 韩士杰,周玉梅,张军辉,王琛瑞,邹春静;Effect of elevated CO_2 concentration on growth course of tree seedlings in Changbai Mountain[J];Journal of Forestry Research;2000年04期
3 Honggang Guo;Shifan Wang;Feng Ge;;Effect of elevated CO_2 and O_3 on phytohormone-mediated plant resistance to vector insects and insect-borne plant viruses[J];Science China(Life Sciences);2017年08期
4 张辉;张红钢;彭大暑;;Hot deformation behavior of KFC copper alloy during compression at elevated temperatures[J];Transactions of Nonferrous Metals Society of China;2006年03期
5 Heng Zhong;Katsushi Fujii;Yoshiaki Nakano;;Electroactive species study in the electrochemical reduction of CO_2 in KHCO_3 solution at elevated temperature[J];Journal of Energy Chemistry;2016年03期
6 ZHU ChunWu;CHENG WeiGuo;SAKAI Hidemitsu;OIKAWA Shimpei;LAZA Rebecca C;USUI Yasuhiro;HASEGAWA Toshihiro;;Effects of elevated [CO_2] on stem and root lodging among rice cultivars[J];Chinese Science Bulletin;2013年15期
7 郑国光;EFFECT OF rhTGF-β1 AND rhGM-CSF ON RECEPTOR EXPRESSIONS IN J6-1 AND J6-2 LEUKEMIC CELLS[J];实验血液学杂志;1995年03期
8 Ji-Xiang Zhang;Jin-Xin Fan;Yun-Teng Liu;Wei Feng;;Superplasticity of 6016 aluminum alloy at elevated temperatures[J];Rare Metals;2015年06期
9 Tao-Hsin Tung;Jorn-Hon Liu;Victor Tze-Kai Chen;Ching-Heng Lin;Chung-Te Hsu;Pesus Chou;;A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan[J];World Journal of Gastroenterology;2005年11期
10 ;Response of phytoliths in Leymus chinensis to the simulation of elevated global CO_2 concentrations in Songnen Grassland,China[J];Chinese Science Bulletin;2010年32期
11 Biplab Hazra;Supriya Bera;Bijay Kumar Show;;Enhanced elevated temperature wear resistance of Al-17Si-5Cu alloy after a novel short duration heat treatment[J];International Journal of Minerals Metallurgy and Materials;2019年03期
12 Crump P A,Crum T R,DeVito M,Farmer J,Grimshaw M,Huang Z,Igl S A,Macomber S,Thiagarajan P,Wise D;High efficiency, high power 808nm laser array and stacked arrays optimized for elevated temperature operation[J];光机电信息;2004年06期
13 DENG Xin Ru;ZHANG Yin Fei;WANG Tian Ge;XU Bai Hui;SUN Ji Chao;ZHAO Lie Bin;XU Min;CHEN Yu Hong;WANG Wei Qing;BI Yu Fang;LU Jie Li;;Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese[J];Biomedical and Environmental Sciences;2014年08期
14 Chen Li;Kun Liu;X.-Grant Chen;;Improvement of elevated-temperature strength and recrystallization resistance via Mn-containing dispersoid strengthening in Al-Mg-Si 6082 alloys[J];Journal of Materials Science & Technology;2020年04期
15 ;Enhanced validamycin production and gene expression at elevated temperature in Streptomyces hygroscopicus subsp. jingangensis 5008[J];Chinese Science Bulletin;2009年07期
16 颜军;朱明光;王明;舒光冀;;THE MICROSTRUCTURE AND PROPERTIES OF ALUMINA FIBER-REINFORCED ALUMINIUM ALLOY MATRIX COMPOSITE[J];Journal of Southeast University(English Edition);1991年01期
17 ;Exposure Brings Understanding[J];Beijing Review;2007年35期
18 Rennenberg Heinz;Matyssek Rainer;;Effects of elevated pO_3 on carbon cycle between above andbelowground organs of trees[J];Journal of Environmental Sciences;2006年05期
19 王健;于智敏;李国勤;张永祥;关崇芬;吕维柏;刘煜;吕维柏;;Clinical Observation on the Therapeutic Effects of Zhongyan-2 Recipe in Treating 29 HIV-Infected and AIDS Patients[J];Journal of Traditional Chinese Medicine;2002年02期
20 王琛瑞,韩士杰,罗兴玻;Photosynthetic response of Pinus sylvestriformis to elevated carbon dioxide and its influential factor analysis[J];Journal of Forestry Research;2000年03期
中国重要会议论文全文数据库 前12条
1 Tian Tian;Xi-run Liu;Ting-ting Li;Zhi-chao Nie;Shuang-jing Li;Yan Tang;Cong-wei Gu;Wang-dong Xu;Hong Jia;;The detrimental effects of long-term elevated serum uric acid on cognitive function in rats[A];达能营养中心第二十三届学术会议——营养与认知论文集[C];2020年
2 Ying Zhou;Yang Hu;Huiping Li;;Role of Propionibacterium Acnes in Sarcoidosis:A Meta-analysis[A];中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议论文汇编[C];2013年
3 李燕;方旭飞;夏彪;冯雪;;In situ measurement of oxidation evolution at elevated temperature by nanoindentation[A];中国力学大会-2015论文摘要集[C];2015年
4 Rao Wang;Pin-Tong Huang;Guo-Qiang Mo;Chun-Mei Liu;Xu Zhang;Cao-Xin Yan;Qing Wen;Min-Qiang Pan;Chao Zhang;;Significance of contrast-enhanced transrectal ultrasonography for the detection of prostate cancer[A];2014年浙江省超声医学学术年会论文汇编[C];2014年
5 ;Physiological response of main tree species in urban forest to elevated CO_2 and O_3 concentration[A];第二届中国林业学术大会——S10 林业与气候变化论文集[C];2009年
6 ;LRP16 is essential for NF-B activation and contributes to elevated NF-B activity in human gastric carcinoma[A];2010’全国肿瘤分子标志及应用学术研讨会暨第五届中国中青年肿瘤专家论坛论文汇编[C];2010年
7 ;Detection of prostate cancer with contrast-enhanced ultrasonographic micro flow imaging:compared with conventional ultrasonography[A];第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会论文汇编[C];2009年
8 蔡振兴;董春香;;Intracranial hemorrhage and history of asymptomatic elevated blood pressure[A];《中华急诊医学杂志》更名十周年、World Journal of Emergency Medicine创刊一周年庆典《中华急诊医学杂志》第十届组稿会、第三届急诊医学青年论坛论文汇编[C];2011年
9 baodi Sun;hongmei Liu;shinan Nie;;S100B protein in serum is elevated after the global cerebral ischemia injury[A];中华医学会急诊医学分会第17次全国急诊医学学术年会论文集[C];2014年
10 李虹;甄立雄;;Epidemiology of Prostate Cancer in Macau S.A.R[A];第十五届全国泌尿外科学术会议论文集[C];2008年
11 YU Jingjin;HUANG Bingru;;Metabolic and proteomic profiling of metabolic pathways associated with improvement in heat tolerance of cool-season grass species by elevated carbon dioxide[A];2013全国植物生物学大会论文集[C];2013年
12 Bin Hua;Ning Yan;骆静利;;Substituted double perovskite oxide with excellent electrocatalytic activity for oxygen reduction reaction at both room and elevated temperatures[A];第三届全国储能科学与技术大会摘要集[C];2016年
中国博士学位论文全文数据库 前1条
1 郭锋;Astrocyte elevated gene-1对肾母细胞瘤生物学行为的影响及分子机制研究[D];山东大学;2014年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978