Health Effects by Neonicotinoid Insecticides
【摘要】：Neonicotinoids belong to a new, widely used class of pesticide, and are applied for agriculture, gardening, pine trees, lawns, animal health, and termite/pest control. With similar chemical structures to nicotine, neonicotinoids also share agonist activity at nicotinic acetylcholine receptors(n ACh Rs). Although their toxicities against insects are well established, their precise effects on mammalian n ACh Rs remain to be elucidated. In Japan, the maximum residual dose for fruits and tea leaves is the second highest in the world behind China, which has no regulations for insecticides. Since 2006, more than one hundred patients have visited same clinic in Gunma with nicotinic symptoms after the consecutive intake of domestic fruit(apples, Japanese pears, peaches, grapes, etc.) and/or tea beverage. These data indicated that the risk of neonicotinoid is comparable to organophosphate.