Gating mechanism of an expressed stretch-activated BKca channel cloned from chick ventricular myocytes

【摘要】：正Voltage-dependent large-conductance Ca~(2+)-activated K~+ Channels(BK)are a unique class ion channel that couple intracellular chemical signaling to electric signals.BK channels are widely expressed in both excitable and non-excitable cells and known be involved in many physiological processes,such as muscle tone regulation,smooth muscle tone regulation and endocrine cell secretion.Although considerable

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